You can select or copy content using the Select tool or the Snapshot tool if the PDF document includes usage rights. These tools recognize and select any content that is visible, regardless of whether the content is on a selected layer.
You can add content, such as review comments, stamps, or form fields, to layered documents just as you would to any other PDF document. However, the content is not added to a specific layer, even if that layer is selected when the content is added. Rather, the content is added to the entire document.